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Брой: 3/1996
Автор: А.-М. Борисова, Д. Коев, Клиничен център по ендокринология и геронтология, Медицински университет – София
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Issue: 3/1996
Author: A-M, Borisova, D. Koev, Clinical Center of Endocrinology and Gerontology, Medical University, Sofia
Abstract:
A 35-year old patient with lasting 19 years insulin-dependent diabetes mellitus, proved by a negative С-peptide level both basal and after simulation with I mg i. v. Glucagon and free from insulin anybodies is described. He was treated with constant subcutaneous insulin infusion using an insulin-pump (Miles, USA) with Actrapid HM insulin (Novo Nordisk) for 9 years and he was taught to keep a diet and follow an appropriate regimen as well as to handle the pump. During the first 5-6 years, relying on the physiological way of insulin administration the patient used to follow a more liberal regimen: he postponed some meals and he missed some snacks. Diabetic retinopathy was found at the 16th year from the onset of diabetes. Then, a period of “hypercontrol" came after, characterized by a fear of high blood glucose levels and diabetic complications. During this 3-year long period the patient added premeal bolus insulins to the usual previous treatment without any blood glucose control and thus iatrogenic hypoglycaemias appeared. This inappropriate behaviour during the first and the second periods of the patient's treatment was the cause for his brittle diabetes mellitus in spite of the usage of a good insulin delivery device. After adjustment of basal insuiin dosage – 1.291 U/h from 8 to 22 h and 1.125 U/h from 22 to 8 h, as well as insulin premeal boluses (5 h before the three main meals and 1 U before the snacks) it was achieved excellent glycaemic control. An individual patient education was performed to make clear that the voluntary interference in the prescribed treatment results in brittle diabetes mellitus.
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